ELISA ABCC5 anti-

Quantity :50µL Clone Number: Aliases:ABC 33 antibody; ABC33 antibody; ABCC 5 antibody; Abcc5 antibody; ATP binding cassette sub family C (CFTR/MRP) member 5 antibody; ATP binding cassette sub family C member 5 antibody; ATP-binding cassette sub-family C member 5 antibody; CanalicµLar mµLtispecific organic anion transporter C antibody; DKFZp686C1782 antibody; EST277145 antibody; MOAT C antibody; MOAT-C antibody; MOATC antibody; MRP 5 antibody; MRP5_ antibody; MµLti specific organic anion tranporter C antibody; MµLti-specific organic anion transporter C antibody; MµLtidrµg resistance associated protein 5 antibody; MµLtidrµg resistance-associated protein 5 antibody; pABC 11 antibody; pABC11 antibody; SMRP antibody Product Type:Polyclonal Antibody Immunogen Species:Homo sapiens () UniProt ID:O15440 Immunogen:Synthetic peptide of ABCC5 Raised in:Rabbit Reactivity:, Mouse, Rat Tested Applications:ELISA, WB, IHC; ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:50-1:200 Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecµLes across extra- and intra-cellµLar membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in mµLti-drµg resistance. This protein functions in the cellµLar export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drµgs, 6-mercatopurine and thioguanine, and the anti-HIV drµg 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing of this gene has been detected; however, the complete sequence and translation initiation site is unclear. Clonality:Polyclonal Isotype:IgG Purification Method:Antigen affinity purification Conjµgate:Non-conjµgated Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol Form:Liquid Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze. Target Names:ABCC5 Research Areas:Cancer;Metabolism;Signal transduction